![]() ![]() Neutralized sodium silicate (1 mg/ml) in dogs leads to rapid urinaryĮlimination of about 50% of the dose (King et al., 1933). Occurring between three to eight hours after dosing. Intragastric 5% silicic acid administered to dogs leads toĬonsiderable absorption and urinary excretion, peak excretion Organ of the body even if animals ingest large amounts of silicates in There appears to be little retention in any With peak excretion in dogs occurring between four to eight hoursĪfter administration. Leading to a rise in urinary silica output without significant Silica dust was administered intragastrically to rabbits and dogs It enters the bloodĬorpuscles at a slower rate (Baumann, 1960). Throughout the whole extra-cellular fluid. Ingested monomeric silicicĪcid rapidly penetrates the intestinal wall and becomes distributed Other substance of high molecular weight. Plasma in a molybdate reactive form and is not bound to protein or any Practically the same as that in the plasma. The normal level of silicic acid in humanīlood is below 1 µg SiO 2/cm 3 the concentration in the corpuscles is Human tissue varies from 10 to 200 mg/100 g dry weight (spleen 15 mg, Order of 10 to 30 mg per day (Thomas, 1965). Urine, which varies considerably according to the diet, is in the Silicic acid is a normal constituent of the urine, where it isįound as early as a few days after birth. Tissues but there is no evidence that they play any physiological Very small amounts of silica are normally present in all body ![]() Food contains various amounts of SiO 2, forĮxample: potatoes 10.1, milk 2.1, drinking-water 7.1, mineral-waterĢ2.5, beer 131 gammaSiO 2 per g or cm 3 (Baumann, 1960). Salts occur ubiquitously in the environment and some have been usedįor many years medically. ![]() Silica, silicic acid and the calcium, magnesium and aluminium The previously published monograph has been expanded and is reproduced Since the previous evaluation, additional data have becomeĪvailable and are summarized and discussed in the following monograph. These compounds have been evaluated for acceptable daily intakeīy the Joint FAO/WHO Expert Committee on Food Additives (see Annex 1, 539 įAO Nutrition Meetings Report Series, 1974, No. Were prepared by the Joint FAO/WHO ExpertĬommittee on Food Additives which met in Geneva,ġ Seventeenth Report of the Joint FAO/WHO Expert Committee onįood Additives, Wld Hlth Org. The evaluations contained in this publication Silicon dioxide and certain silicates (WHO Food Additives Series 5) Toxicological evaluation of some food additives including anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents WHO FOOD ADDITIVES SERIES NO. ![]()
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